David Fidock on antimalarial drug resistance

What happens when the malaria parasite develops resistance to treatment?

David Fidock from Columbia University, USA, describes his research focusing on the mechanisms behind antimalarial drug resistance, as well as the history of these therapies.

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Music
"Intermezzo" and "Tra-la-la" by Podington Bear

Available on the Free Music Archive:
freemusicarchive.org/music/Podington_Bear/Encourag…
freemusicarchive.org/music/Podington_Bear/Encourag…

Additional footage
The dissection of a mosquito for malaria parasite
archive.org/details/Dissectionofamosquitoformalari…

Under CC BY-NC 3.0 licence creativecommons.org/licenses/by-nc/3.0/

Drug resistance in malaria: a review of the west African situation
www.ncbi.nlm.nih.gov/pubmed/1296994

Mefloquine pharmacokinetics and resistance in children with acute falciparum malaria
www.ncbi.nlm.nih.gov/pubmed/1888626

Resistance to artemisinin of malaria parasites (Plasmodium falciparum) infecting alpha-thalassemic erythrocytes in vitro. Competition in drug accumulation with uninfected erythrocytes
www.ncbi.nlm.nih.gov/pmc/articles/PMC293858/

The winged scourge
archive.org/details/gov.archives.arc.47063

Triclosan bound to the parasite enzyme that it inhibits
www.rcsb.org/pdb/explore/explore.do?structureId=1V…

High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery
www.ncbi.nlm.nih.gov/pmc/articles/PMC1797774/

Searching for New Antimalarial Therapeutics amongst Known Drugs
www.ncbi.nlm.nih.gov/pmc/articles/PMC1592519/

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
www.ncbi.nlm.nih.gov/pmc/articles/PMC2440361/

Colorimetric high-throughput screen for detection of heme crystallization inhibitors
www.ncbi.nlm.nih.gov/pubmed/19307367

A Cell-Based High-Throughput Screen Validates the Plasmodial Surface Anion Channel As an Antimalarial Target
www.ncbi.nlm.nih.gov/pmc/articles/PMC2872968/